Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair
Overwhelming lipid peroxidation induces ferroptotic stress and ferroptosis, a non-apoptotic form Bread of regulated cell death that has been implicated in maladaptive renal repair in mice and humans.Using single-cell transcriptomic and mouse genetic approaches, we show that proximal tubular (PT) cells develop a molecularly distinct, pro-inflammator